Speaking to Spark T.V., Eye said Eddy Kenzo, who is the Federation's president, doesn't qualify to hold that position.
Big Eye joined a growing list of musicians that don't see a future in the newly formed the Uganda National Musicians Federation (UNMF).
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Eye who has long-standing beef with Kenzo, who is his former mentor, said that the latter is selfish.
"He is not my president," began Big Eye, real name Ibrahim Mayanya.
"He doesn't qualify to lead musicians because there are many qualifications he doesn't have."
Asked to name Kenzo's weakness, he said: "He doesn't wish well for the industry. He is always frustrating others... He hasn't contributed much to the industry."
Eye, who was speaking from the U.K., said he is establishing connections that he'll share with fellow musicians once he returns.
"For the little time I've spent in the Uk I will share the connections I will have made with fellow musicians," he said.
This is not the first time Big Eye has attacked Kenzo for being selfish though a number of musicians have said good things about how he has supported them.
Musician John Blaq has also said the Federation is being led by people without qualifications and it lacks the professional touch.
King Saha also showed disappointment in the leadership of the association after losing to Bebe Cool for the head of the finance committee during the elections.
UNMF is a collaborative effort of musicians, industry stakeholders, and the Ugandan government, aimed at unifying the music industry in Uganda. The Federation brings together all associations in the industry under one umbrella, promoting growth, collaboration, and unity among musicians and stakeholders.